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KMID : 1134820090380121718
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 12 p.1718 ~ p.1723
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Hemopoietic Effect of Extracts from Four Parts of Deer Antler on Phenylhydrazine-Induced Hemolytic Anemia in Female Rats
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Lee Mee-La
Kim Hyun-Ho
Jo Hyun-Ho
Gu Li-Juan
Ly Sun-Yung
Kang Hyo-Jin
Lee Chung-Ha
Kim Seung-Mi
Yang Sun-Ah
Mo Eun-Kyoung
Sung Chang-Keun
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Abstract
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This study was to investigate the protection of the extracts from four parts of deer antler in an anemia model induced by intravenous injection of phenylhydrazine·HCl (PHZ) at 10 mg/kg for 4 days. After PHZ injection, female Sprague-Dawley rats were administrated partial deer antler extract (200 ㎎/㎏/day, p.o.) daily for 1 week. Results showed that sever hemolysis was induced by PHZ. For antler extract-treated groups, the concentration of hemoglobin, hematocrit and red blood cells number increased much more significantly than PHZ-treated group. Upper antler extract-treated group was more remarkable than other parts in suppressing the increase of reticulocyte in whole blood. Moreover, antler extract administration significantly improved serum erythropoietin concentration. The activity of δ-aminolevulinic acid dehydrates (ALAD) in liver homogenate was increased in antler extract-treated groups, especially middle and base extract-treated groups showed statistical significance. These results could be concluded that the deer antler extract improved anemia induced by PHZ injection through improving hematological values, serum EPO value, ALAD enzyme activity.
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KEYWORD
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phenylhydrazine, anemia, deer antler, hemopoietic effect
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